Toothache and fever can be treated by general treatment, causative treatment and symptomatic treatment. Most of the toothache fever consider wisdom teeth pericoronitis, apical periodontitis and other inflammation due to infection, when the human body is infected with inflammation is more serious, then the symptoms of fever. 1. General treatment: you need to maintain oral hygiene, brush your teeth on time, drink more warm water to promote the metabolism is conducive to fever, and avoid spicy and stimulating food in the diet. 2. Treatment: If the pain and fever caused by wisdom teeth pericoronitis, you can use local rinsing medicine, supplemented by antibacterial drugs such as metronidazole, amoxicillin, to be the inflammation subsides, the wisdom teeth will be extracted; if the apical periapical inflammation caused by the inflammation subsides, you can be through the endodontic treatment, microscopic apical surgery, tooth extraction and other treatments. 3. Symptomatic treatment: patients with more severe toothache symptoms or body temperature over 38.5 ℃, oral ibuprofen particles, ibuprofen particles belong to non-steroidal anti-inflammatory drugs, with antipyretic and analgesic effect. The medication should be taken according to the doctor’s instructions. Toothache fever need to go to the hospital to determine the cause of the disease for targeted treatment. Drugs should be used under the guidance of a doctor.