The so-called painless endoscopy, which can also be called comfort endoscopy, is based on ordinary gastroenteroscopy, in which a certain dose of short-acting anesthetic is first given intravenously to help the patient rapidly enter a state of sedation and sleep, so that he or she can complete the gastroenteroscopy without any consciousness and wake up quickly after the examination is completed. As the patient is painless during the examination, it can avoid the mechanical damage caused by the patient’s unconscious agitation in the painful state, which facilitates the doctor to examine carefully and find the tiny lesions, such as early cancer, earlier. 1.Doing gastroenteroscopy to prevent gastric cancer China is a country with high incidence of gastric cancer, more than half of the new gastric cancer in the world is in China, and every year many people die of gastrointestinal cancer in China, which accounts for about 1/5 of the mortality rate of all tumors. According to the relevant data, in China, the detection rate of early gastric cancer patients is only about 5-10%, and most of the patients are in the middle or late stage when they are found. Timely gastroscopy becomes especially important, as it can visualize the changes in the mucosa and detect different diseases such as gastric ulcers, inflammation, tumors, polyps and so on. We are obliged to call on the public to be aware of medical checkups and to be more vigilant in preventing gastric cancer in time. 2.Why do we need gastroscopy? Most patients think that stomach pain or stomach discomfort is a small thing, take some medicine to reduce the symptoms is good, do not pay attention to the symptoms, the gastroscopy is delayed again and again, often due to recurrent episodes of the disease until the emergence of complications before having to perform a gastroscopy, and it is often too late to regret. A more shocking fact is that the survival rate of early gastric cancer after operation is more than 95%, while that of middle gastric cancer is only 20%. The role of early diagnosis and treatment is self-evident. Gastroscopy can clarify whether there are ulcers, active inflammation, precancerous lesions, tumors, polyps and other lesions, and it can also directly take the lesion tissue for cytology and pathology to obtain pathological diagnostic evidence. Once again, we call on you to do gastroscopy according to the specific condition and doctor’s recommendation in a timely manner, do not wait until the condition worsens to consider doing gastroscopy. 3.Who should have gastroscopy? Generally, we suggest that people over 40 years old should have a gastroscopy every one to two years, and people with symptoms such as epigastric discomfort, dark stools, loss of appetite, weight loss, or people with a family history of gastric cancer or those who live in areas with high incidence of gastric cancer should pay more attention to it. For patients with history of chronic atrophic gastritis, gastric polyps, gastric mucosa enterosis, it is better to have regular gastroscopy if there is no change in their condition, so as to follow up and judge their condition at an early stage. 4.How to read the gastroscopy report? Superficial gastritis: it reflects the infiltration of lymphocytes or plasma cells in the superficial layer of the gastric mucosa, while the deep gastric glands are normal. According to the degree of infiltration of inflammatory cells, patients can be cured after using different drugs. Atrophic gastritis: it is a condition in which, in addition to the presence of inflammatory cell infiltration in the mucosa, partial or complete loss of gastric glands is seen. Atrophic gastritis must be treated aggressively because atrophic gastritis has a higher chance of developing enterochemistry. Enteric chemosis: that is, intestinal epithelial hyperplasia, meaning the appearance of intestinal epithelium in the epithelium of the gastric mucosa, which can be seen in superficial gastritis or atrophic gastritis, but also can be seen in some normal people. Currently, the medical science uses mucus histochemistry, enzyme histochemistry and electron microscopy technology to classify intestinal metaplasia into complete type, incomplete type, and small intestine type or colon type. Most medical experts now believe that incomplete type and colon type enterochemistry (also known as type III enterochemistry) are closely related to the occurrence of gastric cancer. Therefore, further examination should be done after seeing the report of enterochemistry. Individual glandular cystic dilatation: according to the pathologic pattern, gastric mucosal glandular dilatation is divided into simple dilatation and heterogeneous dilatation. Simple dilatation refers to a mild degree of glandular dilatation, which is focal or isolated, with high mucus secretion in the lumen of the gland, no atrophy of the gland, and heterogeneous hyperplasia of the glandular epithelium, which may be accompanied by enterochemistry. It is currently thought that it may be an important precancerous lesion. Therefore, patients with glandular dilatation of the biopsied gastric mucosa, especially those with heterogeneous dilatation, should be reviewed regularly. Gastric mucosal epithelial heterogeneous hyperplasia: also known as atypical hyperplasia. This finding should be given high priority as it can be considered a precancerous lesion. It has been reported that the cancer rate is 2.35% in mild atypical hyperplasia, 4-5% in moderate and 10-84% in severe. In mild cases, gastroscopy should be repeated every 3-4 months, and in moderate cases, every 2-3 months. Severe cases should be treated with surgery as early as possible.