Empty bone marrow after removal of intramedullary nails can be relieved by slow healing, while severe cases need to be treated by surgery. Because bone marrow has a strong regenerative ability, if the bone marrow is empty after the removal of intramedullary nails, you can wait for it to heal slowly, and then slowly fill up the empty bone marrow through its own regenerative ability. If the situation of bone marrow emptying after the removal of intramedullary nails is more serious and does not heal well, you should go to the hospital in time to receive examination, drain the abnormal perfusion of fluid in the bone cavity, and apply the muscle flap filling surgery to fill the eligible muscle flap into the bone cavity. If the bone marrow is empty after the removal of intramedullary nails, it is necessary to pay attention to avoiding wound infection, not to get water on the local area, to disinfect the area regularly, and to actively listen to the doctor’s advice.