Comatose patients can be awakened by drugs, hyperbaric oxygen therapy, sensory stimulation, Chinese medicine methods, etc. Nursing care includes general care and prevention of complications. 1. Wake-up promotion (1) Drugs to promote awakening. Commonly used drugs are catecholamines, such as epinephrine, norepinephrine, dopamine, etc.; choline receptor agonists, such as carbamylcholine, nicotine, etc.; morphine receptor antagonists, naloxone, etc.; nerve growth factor, etc.. (2) Hyperbaric oxygen therapy. Hyperbaric oxygen therapy can increase the blood oxygen level in the patient’s body and eliminate cerebral edema, thus promoting the awakening of comatose patients and improving their vital functions. (3) Sensory stimulation. Methods such as auditory call, visual call, taste call, tactile call, music therapy, etc. may have the effect of stimulating the activity of cerebral cortex, thus improving the clinical symptoms and promoting the awakening of comatose patients. (4) Traditional Chinese medicine methods. Promote the awakening of comatose patients mainly through acupuncture, which needs to be operated by specialized doctors. 2. Nursing care (1) General nursing. Monitor the patient’s vital signs, pupils, and consciousness; also need to wash the mouth, clean the skin and other care. (2) Prevention and treatment of complications. It is necessary to pay attention to the cleanliness of the patient’s urinary system, so as to prevent urinary tract infections; do a good job of oral care, timely removal of foreign bodies in the mouth and nose, to prevent aspiration pneumonia; turn over and pat the back diligently, and carry out sputum suction operation when necessary, to prevent aspiration pneumonia and pressure ulcer prevention; move the limbs or the affected limbs as early as possible, and carry out reasonable limb massage. The treatment and care of comatose patients should be under the guidance of doctors, and the use of medicines should follow the doctor’s instructions.