Frequent stomach pain in the middle of the night is mostly considered to be caused by duodenal ulcer. Patients with duodenal ulcer are often prone to night pain and hunger pain, but other acute and chronic gastrointestinal diseases such as acute gastritis, chronic gastritis, gastric ulcer, gastric cancer, esophageal, gastric and duodenal diverticulitis, reflux esophagitis, etc., or intestinal dysfunction due to improper diet are not excluded. When these conditions occur, gastroscopy should be performed to understand whether there are organic lesions and give comprehensive treatment. Often stomach pain in the middle of the night, daily life should eat more warm, soft, light, easy to digest food, avoid overeating, avoid the intake of raw, cold, spicy, greasy and other irritating food, to eat less and more, chew slowly, ensure sufficient sleep, appropriate exercise to promote recovery.