Ibuprofen has anti-inflammatory, analgesic and antipyretic effects. It has a long-lasting antipyretic effect and is more effective than acetaminophen in reducing fever above 39 °C. It is also recognized as the preferred anti-inflammatory for children…. …6 hours/time, up to 4 times a day. It is permitted in the United States for use in children ≥6 months of age. Acetaminophen (paracetamol) is a nonsteroidal anti-inflammatory and antipyretic analgesic used for migraine, headache, and fever…WHO recommends it as the antipyretic of choice for fever in infants and children over 3 months of age. Acetaminophen is rapidly and completely absorbed and produces an antipyretic effect within 30 min of oral administration. It is important to note that most commonly used children’s compounded cold medicines also contain acetaminophen. Acetaminophen is given at 4-6 h intervals, up to 4 times a day.