Syphilis stage II can be cured with aggressive and effective treatment, because syphilis stage II is mainly a skin change and has not yet damaged multiple organs. When entering the third stage, bone syphilis, neurosyphilis and cardiovascular syphilis will appear. Even if the syphilis spirochetes can be removed through treatment, it is difficult to reverse the organs that have been damaged. The second stage of syphilis is still early because there is no damage to various organs, so the second stage is still early, the first and second stage of syphilis are very infectious, mainly penicillin treatment is preferred, the course of treatment for two weeks, after the cure to follow the doctor’s instructions for regular check-ups, monitoring changes in the condition, because syphilis may also appear recurrence or re-infection, the key to the prognosis of syphilis is early detection, early diagnosis, early treatment.