Syphilis is a relatively complex venereal disease that can invade all systems of the body. It can have no clinical manifestations and is medically known as latent syphilis, which is infectious. Many patients are discovered during pre-pregnancy, pregnancy check-ups or pre-operative examinations; they can also have a variety of clinical manifestations, such as neurological symptoms such as walking on cotton, blurred vision, and a variety of skin manifestations, which can resemble the manifestations of many skin diseases, such as pityriasis rosea, psoriasis, eczema, etc. Some patients with syphilis can be accompanied by hair loss, so for those who have the above clinical manifestations, they should be promptly The patient should be diagnosed and treated as early as possible to reduce the risk of transmission to others and to reduce the risk of syphilis spirochetes to the patient. For latent syphilis, from the point of view of public health, this part of the population should be paid more attention to, because there is no clinical manifestations, easy to be ignored by the patients themselves and doctors, not only to the surrounding people, especially sexual partners pose a threat, but also delay the disease and even cause some irreversible damage to tissues and organs. Therefore, it is very necessary to do STD testing for people with multiple partners or spouses with multiple partners.