Acne that is painful to the touch and has hard lumps usually belongs to nodular acne or cystic acne, which is a severe form of acne and is recommended to be improved by general treatment, oral medication or topical medication under the guidance of a doctor. 1. General treatment: Patients should pay attention to facial cleanliness, avoid squeezing the acne with hands to prevent infection, and recommend a light diet and avoid spicy and stimulating foods. 2. Oral medication: For severe acne, it is recommended that patients take oral isotretinoin, minocycline hydrochloride or doxycycline hydrochloride under the guidance of a doctor to improve. 3. Topical medications: For severe acne, there is usually an inflammatory reaction, so anti-infective drugs can be used topically, such as fusidic acid cream, mupirocin ointment and so on. For patients with acne with hard lumps and pain, it is recommended to go to a regular hospital for timely examination and active treatment under the guidance of a doctor. The above drugs should be used under the guidance of professional doctors.