Paracetamol, whose generic name is acetaminophen, is an antipyretic and analgesic used for routine pain relief and fever reduction. Adverse reactions include rash or itching, hives, drug fever, hypersensitivity, and liver and kidney impairment. Acetaminophen is contraindicated in people who are allergic to acetaminophen and those with severe liver or kidney insufficiency. Acetaminophen preparations include tablets, powders, capsules, solutions, etc. For each preparation, the packaging and sealing environment are different. Taking conventional tablets as an example, they are usually packaged with aluminum foil for pharmaceutical packaging, and the expiration date ranges from 18 to 24 months. When the drug expires, the sealing environment of the aluminum foil may have been damaged, and bacteria and foreign objects may contaminate the drug, which may cause gastrointestinal discomfort after taking it. After the expiration date, the active ingredients of the drug may evaporate or deteriorate, and the efficacy of the drug may not be good, which may delay or aggravate the condition. Do not take medicines after the expiration date. The use of drugs must follow the doctor’s advice, not blindly use their own medicine, so as not to cause adverse consequences.