Sleep deprivation can cause headache. If lack of sleep for a long time, it may cause ischemia and hypoxia in the brain. Chronic ischemia and hypoxia in the brain can cause ischemic-hypoxic encephalopathy, and patients can have headache, nausea and vomiting, as well as memory loss, inattention and incoherent thinking. In severe cerebral blood supply deficiency, dementia may be caused. The main treatment is to regulate the nerves, and at the same time should be given to improve the brain metabolism treatment, the drugs to regulate the nerves can be taken orally glutamatergic, tranquilizing and brain tonic liquid, also can be taken orally cardiac tranquilizer tablets and nourishing blood and clearing brain granules. Drugs to improve cerebral metabolism are generally used in the form of olanzapine, piracetam and cytidylcholine. If the patient has a severe headache, symptomatic pain relief treatment can also be administered orally with ibuprofen, indomethacin and naproxen. In addition, if the patient is sleep deprived, it may also cause an increase in blood pressure. Patients with elevated blood pressure can also develop headache, and if the blood pressure is elevated, blood pressure lowering treatment should be given. Commonly used blood pressure lowering drugs include levamlodipine, amlodipine besylate, valsartan and irbesartan.