Progesterone is a progesterone hormone secreted by the ovaries, which is at a high level during pregnancy and remains relatively stable in the body every 24 hours, and usually does not change due to diet. The level of progesterone secretion is mainly related to the embryo implantation in the uterine cavity, the quality of the embryo and the luteal secretion function of the ovary. If the embryo is poorly implanted in the uterine cavity, the embryo is of poor quality or the ovarian corpus luteum is poorly functioning, the progesterone level will be low both on an empty stomach and after a meal. Progesterone can be measured after pregnancy to help reflect the development of the embryo in the uterine cavity in the early stages and to determine the possibility of preterm abortion. In case of low progesterone, women should be alert to the occurrence of ectopic pregnancy, pre-eclampsia or embryonic development arrest, and can apply progesterone, dydrogesterone and other medications for fetal preservation treatment under the guidance of a doctor. If the embryo has stopped developing, the pregnancy should be terminated promptly. In addition to the progesterone level, the blood HCG level should also be tested in early pregnancy, which can reflect the early embryonic condition comprehensively, and if any abnormality occurs, it should be treated promptly under the guidance of doctors. However, during the non-pregnancy period, especially during the ovulation promotion process of IVF, the measurement of progesterone is more accurate in the morning on an empty stomach. During this procedure, a small increase in progesterone is an important indicator of egg maturation. The secretion of sex hormone binding globulin by the liver increases after eating and especially after drinking large amounts of water, which affects the level of progesterone in the blood.