The use of immunosuppressive agents should be guided by renal biopsy, and the therapeutic goal is to achieve complete remission of renal damage (urine protein <0.5 g/d, normal or near-normal renal function); 2. Hydroxychloroquine is appropriate for all patients with lupus nephritis; 3. The initial treatment regimen for patients with III-IV(A) or (A/C) (±V) lupus nephritis (International Society of Nephropathology 2003 classification criteria) is mycophenolate For patients with clinical and histologic features with poor prognosis, higher doses of cyclophosphamide may be used, while azathioprine may be used in patients with milder disease; 5. 6. for patients who improve on initial therapy, continue immunosuppressive therapy with mycophenolate or azathioprine for at least 3 years, and for those who fail mycophenolate or cyclophosphamide therapy, switch to other drugs or rituximab; 7. for patients who want to become pregnant, change to other appropriate drugs, but the intensity of therapy remains the same; 8. there is no evidence that the treatment of lupus nephritis in children and adults differ.