Clinical decision on antiviral therapy is not based on the amount of hepatitis B virus alone. A comprehensive assessment of the progress of the disease is needed to decide whether antiviral treatment is needed. According to the relevant recommendations of the new International Epidemiologic Guidelines for the Treatment of Chronic Hepatitis B, antiviral therapy can be initiated when hepatitis B virus DNA is positive and ALT (alanine aminotransferase, previously known as glutamic acid transaminase) appears abnormally elevated, and other causes such as drug-induced hepatitis and steatohepatitis have been ruled out. There are no specific rules for viral load and ALT levels. In addition, long-term antiviral therapy is also required when there is histologic damage to the liver, such as cirrhosis. Due to wide individual differences, medication and treatment need to be tailored to the individual. Therefore, when suffering from hepatitis B, one should seek medical attention. The doctor will assess the need for antiviral treatment according to the individual’s condition. At the same time, the appropriate treatment plan should be formulated. Do not use medication on your own to avoid further liver damage caused by improper use of medication.