Persistent chest pain is usually considered to be related to pleurisy, costochondritis, cholecystitis, reflux esophagitis, coronary artery disease and other diseases, which need to be further examined in the hospital to clarify the cause of the disease, and then consult the doctor in time. 1. Pleurisy: generally due to the irritation of the chest by the inflammatory mediators of the pleura, the phenomenon of chest pain, pleurisy may be coughing, chest tightness and other symptoms. 2. Costochondritis: it is usually due to the stimulation of the rib cartilage in the movement and other factors, causing chest pain, costochondritis will usually appear swelling and other symptoms. 3. Cholecystitis: It may be due to the stimulation of gallbladder inflammatory media, resulting in pain around the gallbladder and pulling the chest, causing chest pain, cholecystitis usually has nausea and other symptoms. 4. Reflux esophagitis: it is usually due to reflux esophagitis that causes the stomach to secrete a large amount of gastric acid, causing chest pain, and reflux esophagitis may cause reflux and other symptoms. 5. Coronary heart disease: Chest pain is usually caused by narrowing or blockage of arteries due to coronary heart disease, and coronary heart disease usually results in symptoms such as chest tightness. If the phenomenon of persistent chest pain, it may also be related to duodenal ulcer, joint muscle strain, pneumothorax and other diseases. In daily life, you should pay attention to rest, appropriate exercise, and maintain a relaxed and happy mood.