Waking up every morning with lower abdominal discomfort may be caused by gastrointestinal dysfunction, inflammatory bowel disease, pelvic inflammatory disease and other diseases, which need to be targeted treatment under the guidance of the doctor, such as medication, surgery and so on. 1. Gastrointestinal dysfunction: when accompanied by constipation, it can be treated with laxatives such as polyethylene glycol and gastric stimulants such as domperidone, as well as probiotics such as Bifidobacterium bifidum and Bacillus licheniformis. 2. Inflammatory bowel disease: it can be treated with mesalazine, which can inhibit the inflammatory reaction of the intestinal wall, and hydrocortisone can be used to control the condition, and those with intestinal hemorrhage or perforation need to be operated. 3. Pelvic inflammatory disease: can use metronidazole, clindamycin and other antibiotic treatment, drug treatment is ineffective or abscess persistence and other conditions such as surgical resection is recommended. Wake up every morning in the lower abdomen discomfort is recommended to go to the hospital, ask the doctor to make a judgment, clear the cause of the disease.