Headaches after surgery for pituitary tumors of the brain are very common in clinical practice. If it is accompanied by nausea, vomiting, vision loss, it is necessary to review the head CT, to be alert to the pituitary tumor accompanied by rebleeding. If there are no problems with the CT scan, pain medications can be used. If there are problems, surgery should be performed to remove the hematoma, stop the bleeding, and administer oral pain medications, such as Loxoprofen and Acetaminophen. If oral medications do not improve the situation, intravenous medications, such as ketorolac tromethamine injection, can be applied. If there is still no effect, then narcotic sedative medications can be applied, such as morphine, fentanyl, and remifentanil. If there is still no relief, it is important to review the head CT again to check the intracranial situation, because at this time the headache should also be identified with migraine or mental anxiety, tension headache and subjective headache, so if it still can’t be resolved, improve the examination to exclude the diagnosis before the final treatment.