Bacterial prostatitis take a kind of antibiotic is ineffective, should be replaced to take other antibiotic drugs, and in serious cases, the use of surgical treatment. 1. Replacement of drugs: (1) drug resistance: when a patient with bacterial prostatitis takes an antibiotic that is ineffective, it can be considered that the causative organism has become resistant to the antibiotic taken. At this time, the patient can carry out bacterial culture and drug sensitivity test, according to the results of drug sensitivity to choose other antibacterial drugs, such as metronidazole. (2) Wrong medication: patients may not have carried out bacterial culture tests in the early stage of the disease, resulting in the medication taken not being able to remove the bacteria in the body. For example, if you have taken penicillin for anti-positive cocci, you can take broad-spectrum antibiotics, such as cefepime, for subsequent treatment. 2. Surgery: If the bacterial prostatitis patients take any antibiotics are ineffective, it is considered to be because the infection is aggravated, and if it also triggers an abscess, then surgical treatment should be used to relieve the symptoms, such as transurethral resection of the prostate, transurethral cystocervical incision, and so on. The above mentioned drugs should be used under the guidance of the doctor, bacterial prostatitis take antibiotics is ineffective, need to go to a professional hospital, under the guidance of the doctor for examination and treatment, and strive for a speedy recovery.