1.People who are not quite mentally normal and have poor self-control. 2.Allergic people or those who are allergic to toxin or human albumin. 3.Pregnant women (including those who have pregnancy plans within 6 months) and lactating women. 4.People with motor neuron disease or muscular system disease (such as myasthenia gravis, multiple sclerosis, Lambert-Eaton syndrome, ptosis, etc.). 5, people who have used drugs that have an effect on the metabolism of toxins or are prone to bleeding and edema within two weeks (such as aminoglycoside antibiotics, penicillamine, quinine, morphine, calcium antagonists, aspirin, hormones, etc.), which can increase the toxicity of toxins. 6, fever, acute infectious diseases, heart, liver, lung, kidney and other important organ diseases, connective tissue disease, active tuberculosis, blood diseases and children under 12 years of age. 7, very thin people: because the muscle is too thin, it is easy to diffuse to the surrounding muscles after injection and side effects can easily occur.