The HPV infection can cause diseases such as plantar warts, condyloma acuminatum, flat warts, and so on, and the symptoms of different diseases are different. 1. metatarsal warts: metatarsal warts can occur in any part of the soles of the feet, the rash is initially small, flat pimples, with the development of the disease, gradually increased to the size of a soybean, the patient in the standing or walking pain, some patients may also have no symptoms; 2. acromegaly: acromegaly generally occurs in sexually active young and middle-aged people, the initial stage is usually manifested in the external genitalia and perianal skin mucous membrane small pimples, a few patients will appear sexual movement discomfort, bleeding, pain, itching and other symptoms, with the progression of the disease, the pimples gradually increase, can be cockles, cauliflower-shaped, and so on; 3. flat warts: flat warts are often manifested as different sizes of slightly elevated flat pimples, generally rice grains to soybean size, mostly in the forearms, back of the hand, face and other parts of the body, usually no symptoms, some patients will have a slight itching. If the above symptoms occur, should promptly go to the hospital for medical treatment, clear diagnosis and follow the doctor’s instructions for treatment.