Patient: Description (onset, main symptoms, hospital, etc.): Hello, thank you for your answer! We have a genetic diagnosis: male: heterozygous for the SEA deletion type a gene, female: heterozygous for the B-luciferin gene at locus 654. Do I need to do any further tests now that I am ready to have a baby? And what kind of folic acid should the woman take if she wants to take folic acid before pregnancy? Is Fosfom available in the market? I heard from my friends that it is good, but I am special, so please give me advice on what kind of folic acid and vitamins to take? My husband was detected with a thalassemia gene test Test method: PCR method Result: SEA deletion type a thalassemia gene heterozygote was detected, type 37 and 42 were not detected; B thalassemia Test method: reverse speckle hybridization Result: PCR combined with reverse speckle hybridization showed that no mutation was seen in the common 14 mutation loci of the B-bead protein gene. Is it true that the doctor previously said that having a child with a different type does not affect it? Will the baby born be healthy? I looked up on the internet and it says that it is possible for a to be present at the same time as the B gene, or is it necessary for B to be present at the same time as the a. Do we need to do more detailed tests? I’m afraid I’ll have an unhealthy baby, please advise me! Thank you! Yang Hongchong, Hematology Specialist, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine: Unfortunately, there is still no medical solution (including drug therapy) to prevent thalassemia from being passed on to offspring. Combining patients with different types of thalassemia may give birth to a child with mixed thalassemia. As a last resort, amniocentesis in the sixth month of pregnancy can be considered before deciding on the trade-off; however, it is not foolproof. The best thing to do is not to have children!