The skull has its own sacred mission for human health, and it is relatively hard, but there are always some unavoidable factors that cause skull defects in life. Cranial defects will certainly bring different degrees of health effects, so when there is a problem of cranial defects, the only thing to face is to take cranial repair surgery, so as to avoid other unnecessary damage. For skull repair surgery, many patients are concerned about the approximate cost of skull repair materials. First of all, the cost of skull repair surgery is an inexact value, which includes various costs, such as preoperative examination, hospitalization and surgery, and the cost of surgical materials. In addition, different patients’ conditions and different hospitals’ charges will affect the cost of skull repair surgery. There are many factors affecting the cost of skull repair surgery, and the skull repair material chosen will be an important factor affecting the cost of skull repair surgery. Good cranial repair materials will be more effective and the cost may be relatively higher. From ancient times to the present, there are still many materials used for skull repair, from the initial human bone and plexiglass to the more widely used titanium mesh material now. Titanium mesh may have some progress and advantages compared with some materials once, but there are also many problems. It is found in clinical surgery that patients who use titanium mesh material for cranial bone repair are extremely prone to postoperative infections, large rejection reactions, and even possible exposure of titanium mesh, so it is not ideal for titanium mesh material in cranial bone repair surgery. The PEEK material has incomparable advantages over all previous materials, as it is a three-dimensional material that can truly restore the anatomical structure of the human skull, with excellent properties comparable to those of autologous skull bone. There are no rejection or infection problems, and the use of PEEK for cranial repair will not interfere with future medical examinations. In short, PEEK is the ideal material for cranial repair because of its perfect repair results.