Leukoplakia is the collective name of some diseases with white spots on the skin as the main symptom, caused by more etiologies, such as vitiligo, white pityriasis, anemic nevus, etc.. Sweat spot has a single cause, fungal infection, and the two can also be distinguished from the onset of the site, symptoms, and treatment.1. Different causes: white spots have many causes, which can be acquired congenitally and acquired, both intrinsic and external environmental causes. Intrinsic causes such as vitiligo, white furuncle, anemic nevus, etc.; external environmental causes such as sun exposure, chemicals, but also due to fungal infection. The sweat spot disease is caused by fungal infection, such as infection with Malassezia furfur, and caused by a state of skin performance; 2, the onset of the site is different: the onset of white spots can be generalized, can also be limited to occur, the face and hands and feet are more common. The onset of sweat spots is more limited, usually in the parts with developed sebaceous glands and easy to sweat, such as arms, neck, chest, and back; 3, the symptoms are different: white spots are white in color, round or oval in shape, the edges are not clearly bounded with the surrounding area, the surface is smooth, no scales, and the hair in the white spot area is also white, usually without conscious symptoms. The color of sweat spot is not only white, sometimes it is accompanied by other colors, the shape can also show irregular shape in addition to round or oval, the surface of the lesion is not smooth, like a flower spot, there will be fine scales, the hair is not white, slightly itchy; 4, the treatment is different: in the early stage, if the cause of the disease is clear earlier, the condition is mild, the area of the white spot is not large, and there are still surviving melanocytes in the white spot, this The treatment at this time is easy to cure the disease or control the disease from progressing. However, if the lesion is more obvious, due to more causes, the specific treatment needs to be analyzed according to the specific condition and then determine the treatment plan. If the lesion area is large and the disease is heavy, or if the effect is not obvious through external treatment, it can be treated with oral antifungal drugs, which is more effective.