Leukemia patients with head discomfort may be caused by leukemia involving the nervous system, but head discomfort may also be caused by physiological factors or other craniocerebral lesions, extracranial lesions and other factors, and need to be further clarified after diagnosis to be targeted treatment. 1. Leukoencephalopathy involving the nervous system: leukoencephalopathy can involve the nervous system, cardiovascular system and other systems with the progression of the disease, when it involves the nervous system and causes damage, the patient can appear headache, mental abnormality, optic disc edema and other symptoms, this situation needs to comply with the doctor’s advice and actively use glucocorticosteroids, such as prednisone and other immune-suppressing agents, such as azathioprine and other medications for the treatment of leukoencephalopathy. 2. Physiological factors: Insufficient rest time, environmental stimulation, tension and other physiological factors may lead to head discomfort, which can be relieved after sufficient rest and emotional stabilization. 3. Other craniocerebral lesions: encephalitis, meningitis, cerebral infarction and other craniocerebral lesions other than leukoencephalopathy involving the nervous system may cause head discomfort, which need to be further diagnosed and targeted treatment. 4. Extracranial lesions: patients with neuralgia, cranial tumor, cervical spondylosis and other extracranial lesions may also experience head discomfort, which should be diagnosed after relevant examinations and treated with medication and other treatments according to the cause of the disease. Patients with leukemia may have other reasons for head discomfort, and it is recommended that patients go to the rheumatology and immunology department of regular hospitals, neurology department and other related departments for further consultation and treatment according to the doctor’s instructions.