Glycated hemoglobin is a product formed by the reaction between glucose in plasma and hemoglobin in blood, which is affected by blood glucose and hemoglobin, and reflects the overall blood glucose level in the recent 2 to 3 months. High glycated hemoglobin despite low blood glucose before and after meals may be due to the effect of hemoglobin.
Splenectomy, impaired red blood cell clearance, decreased reticulocyte production, aplastic anemia leading to prolonged red blood cell life span, hypertriglyceridemia and hyperbilirubinemia, genetic or chemical alterations in hemoglobin such as hemoglobinopathies, methaemoglobin, and other factors may lead to high glycosylated hemoglobin.
A person with high glycosylated hemoglobin but not high blood glucose before and after meals should go to the hospital for further clarification of the cause and treatment under the guidance of a doctor.