Herpes at the corners of the mouth was previously thought to be caused by “fire”, but modern medicine considers it to be a skin disease characterized by clusters of blisters caused by herpes simplex virus infection when the body’s immunity is low, called herpes simplex. Herpes simplex is self-limiting and can get better on its own in 1-2 weeks, but it is prone to recurrence and can be treated symptomatically to shorten the duration of the disease and reduce the chance of recurrence and transmission. Treatment is mainly divided into the following aspects: 1. lifestyle habits, do not lick the corners of the mouth with your tongue, saliva remains at the corners of the mouth, which can easily form a hypertonic environment, leading to local erosion and secondary bacterial infection; 2. at the onset of the disease, it is best to choose oral antiviral drugs as prescribed by the doctor before the appearance of skin herpes or within 24 hours, the course of treatment is usually 5 days; if more than 6 times a year, you should eat 6-12 months of continuous antiviral drugs. If the symptoms are severe, intravenous administration is required, and the specific dose and time should follow the doctor’s prescription; 3. Keep the affected area dry and use topical antiviral ointment such as acyclovir, and add antibacterial ointment such as mupirocin when there is secondary infection. Herpes is contagious when it ruptures, it is best not to kiss or use other people’s utensils or lip balm. When the body’s resistance is poor, such as staying up late, overworking, mental stress, menstrual period, cold, etc., the latent virus can become active again and cause recurrent herpes.