The incidence rate of liver cancer ranks fifth among malignant tumors worldwide, and China is a large country of liver cancer, with the annual incidence rate accounting for about 55% of the world, which is the third highest in China, and the mortality rate is the second highest. Therefore, the earlier liver cancer is detected, the better the treatment effect! So how can liver cancer be detected at an early stage? There are many articles on clinical signals that can indicate early liver cancer, mentioning that patients should be highly alert to the occurrence of liver cancer if there are clinical symptoms such as pain in the liver area, loss of appetite, weakness or even wasting, etc. In fact, once these clinical symptoms appear, the liver cancer identified by examination is often in the middle and late stage, because the liver is solid and generally patients with tumors of 3-5cm in diameter in the liver often have no abnormal feelings. Because the liver is solid, patients with 3-5 cm diameter tumor in the liver usually do not feel anything abnormal, and systemic manifestations such as loss of appetite and wasting are even more rare. Therefore, early detection of liver cancer cannot be confirmed by physical examination after discomfort, but by physical examination! A simple abdominal ultrasound can detect liver masses of 1cm or more in diameter. Given that 90% of liver cancer patients in China are combined with hepatitis B virus carriers or major and minor triplets, hepatitis B virus – cirrhosis – liver cancer is known as the “trilogy”, China is a big country of hepatitis B, so it has also become a big country of liver cancer. AFP is a more specific tumor marker for liver cancer, more than 70~80% of liver cancer patients have elevated AFP, if pregnancy, active liver disease and embryonic reproductive tumor can be excluded, elevated AFP should be highly alerted to the occurrence of liver cancer, which is often detected earlier than imaging. can often precede the imaging manifestations. If AFP is found to be elevated but abdominal ultrasound does not reveal liver abnormalities, abdominal enhanced CT or MRI should be performed, which is much more accurate than abdominal ultrasound. If there is no abnormal finding, AFP and abdominal ultrasound/CT should be followed up closely every 1~2 months, and once small liver cancer lesions are found, the effect of early treatment is of course very ideal!