A toothache may cause facial swelling, and there is no fastest clinical way to reduce the swelling. It is recommended to look for the cause of the toothache, and the facial swelling can gradually subside once the patient’s condition is under control. Toothache is mainly considered to be related to oral diseases, such as acute apical inflammation may lead to toothache and facial swelling. It is recommended to go to the hospital stomatology department for examination, to establish a smooth drainage, can drain out the exudate and pus, if necessary, with oral metronidazole, amoxicillin, ofloxacin and other drugs to control the infection, the inflammation can be controlled as soon as possible after the swelling subsides. Acute wisdom teeth pericoronitis can also lead to toothache, face swelling, you can go to the hospital stomatology for pericoronary blind pocket irrigation, remove the inflammation, swelling can subside as soon as possible. In summary, toothache is considered to be related to pathological factors, which may lead to serious recommendations combined with the doctor’s opinion, for the treatment of primary diseases, can promote the swelling to subside. Drugs should be used under the guidance of a physician.