Pustular acne is classified as Grade III or IV moderate-to-severe acne and can be intervened with topical medications, oral medications, and topical treatments. 1. Topical medication: For grade III or IV moderate-to-severe acne, topical medications such as retinoids, benzoyl peroxide, antibiotic ointment, and selenium dioxide are usually needed. 2. Oral drug therapy: oral isotretinoin and other drugs, combined with antibiotic therapy, such as minocycline, doxycycline, etc., but also under the guidance of the doctor to apply hormone drugs, such as anti-androgen drugs (such as ethinyl estradiol cyproterone, etc.) or glucocorticosteroids (such as prednisone, etc.), the use of these drugs should be ensured to ensure the standardization of the use. 3. Local treatment: including physical therapy and chemotherapy, but it should be noted that the above treatments should be carried out under the guidance of professional physicians. (1) Physical therapy: red and blue light irradiation, photodynamic, laser and other treatments can be used to reduce inflammation, inhibit the secretion of sebaceous glands and improve symptoms. (2) Chemotherapy: Including the application of fruit acid treatment, which can accelerate the shedding and renewal of epidermal cells and regulate sebum secretion. It is recommended that patients with moderate-to-severe acne go to the hospital in time, and standardize the use of medication under the guidance of a doctor. The above medications, especially retinoids, should be used under the guidance of a clinician, and self-medication is prohibited.