The man has thalassemia and the woman needs amniocentesis for prenatal diagnosis. Thalassemia is an anemia with impaired production of beads and is a common genetic defect. Prenatal diagnosis is required when one of the spouses has a congenital disorder, a genetic disorder, or a family history of a genetic disorder. If the male partner has a genetic defective disorder, the female partner needs to undergo amniocentesis for prenatal diagnosis. Thalassemia may be present in the fetus when the male partner has thalassemia, regardless of whether the female partner has thalassemia. When the male partner has thalassemia, prenatal diagnosis can be made by performing chorionic villus aspiration in early pregnancy and amniocentesis in mid-pregnancy to reduce the birth of children with thalassemia. Couples whose male partner has thalassemia should consult the prenatal diagnosis clinic of regular hospitals in a timely manner and conduct prenatal diagnosis under the guidance of professional doctors, so as to reduce the birth of genetically defective fetuses.