Treatment of nail fungal disease (gray nail) is currently mainly oral antifungal drugs, the most common being itraconazole, 200mg/dose, 2/day, taken for one week and stopped for 3 weeks, for a total of 3-4 courses; or terbinafine hydrochloride, 250mg/day, for 2-3 months. These two drugs are relatively safe, but they may also have some effect on liver function, which is manifested in the clinic as increased transaminases in a small number of patients after taking the drug for a period of time, but such changes are reversible and can be recovered after stopping the drug. There are many reasons for elevated aminotransferases, such as hepatitis, cold, medication, exertion, etc. Whether it is a long-term aminotransferase abnormality or an accidental situation. If the elevation is only accidental, you can still take oral medication and review liver function every month. Even if the aminotransferase is elevated for a long time, you can still use oral medication in the case of liver function testing! The actual fact is that you can find a lot of people who are not able to take care of their nails! Topical ointments and solutions are not effective in treating nail fungus because the medication does not penetrate the nail plate. However amorolfine rub or bactrim rub can be used for mild to moderate onychomycosis in uninfected nail halves.