The presence of urinary microalbumin in diabetic patients generally represents the progression of diabetic nephropathy to stage III. The first one, to strictly limit the intake of protein in food and carry out a high quality protein diet. The second, to strictly control blood glucose, control fasting blood glucose to less than 7.0 mmol/L, postprandial blood glucose to less than 10.0 mmol/L, and glycated hemoglobin to less than 7%. Thirdly, strict control of blood pressure to less than 125/75mmHg. Fourthly, it is recommended to use ACEI or ARB drugs, which can reduce proteinuria and delay the decline of GFR in addition to lowering blood pressure, and can also delay the progression of nephropathy. Even if the patient does not have hypertension, it is recommended to use ACEI or ARB drugs to reduce proteinuria. Fifthly, patients are recommended to use some drugs to improve microcirculation, such as Yikai and Tanglin. The patient’s diabetic nephropathy is a microvascular complication, at this time, it is recommended that the patient undergoes fundus examination to clarify the presence of diabetic retinopathy for early detection and treatment.