The main difference between Compound Cold & Flu Spirit and Cold & Flu Spirit is the difference in drug ingredients and indications. 1. Ingredients: Compound Cold & Flu Spirit includes honeysuckle, five-fingered citrus, wild chrysanthemum, trigonelline, southern bluebell root, post plum, acetaminophen, chlorpheniramine maleate, and caffeine. Cold & Flu mainly contains Trigonelline, Gangplum, Chlorpheniramine Maleate, Calendula Officinalis, Caffeine, Peppermint Oil, Wild Chrysanthemum, Acetaminophen. 2. Indications: Compound Cold & Flu Relief can relieve epidermis with pungent coolness, clear away heat and detoxify toxins. It is suitable for wind-heat cold with fever, slight aversion to wind-cold, head and body ache, dry mouth and thirst, nasal congestion with turbid nasal mucus, sore and swollen throat, cough and yellowish sticky sputum. It is contraindicated in severe hepatic and renal insufficiency. Adverse reactions include drowsiness, somnolence, thirst, feeling of weakness. Cold and Flu Relief can relieve fever and analgesia, and is indicated for headache, fever, nasal congestion and runny nose, sore throat caused by cold and flu. It is contraindicated in severe hepatic and renal insufficiency. Adverse reactions include sleepiness, drowsiness, thirst, and feeling of weakness. Patients with cold and flu symptoms are advised to use the medicine under the guidance of a professional doctor to avoid delay.