Gallstone disease is a common and frequent disease, including stones occurring in the bile ducts and gallbladder. With the improvement of people’s living standard, the incidence of gallbladder stones in China is gradually increasing. Patients with gallstones are usually asymptomatic or have only upper abdominal discomfort, and are mostly found by chance during physical examinations or imaging examinations for other diseases. 1. Gallbladder stones. The symptoms depend on the size and location of the stones, as well as the presence of obstruction and inflammation. (1) Most patients are asymptomatic and 80% of gallbladder stones are found during physical examination. (2) Larger stones can cause colic in the upper middle or right abdomen, and the pain can radiate to the back and shoulders. There will be indigestion symptoms such as belching after eating fatty foods or full meals, which is often misdiagnosed as stomach cramps and gastric ulcers. (3) Smaller stones cause biliary colic and acute cholecystitis after a full meal, eating fatty foods, or after lying down at night with stones obstructing the gallbladder duct. (4) Due to the contraction of the gallbladder, smaller stones may enter the common bile duct through the cystic duct and cause obstructive jaundice. (5) When stones obstruct the bile duct for a long time without co-infection, only gallbladder fluid is formed, and then an enlarged gallbladder without obvious pressure pain can be palpated. (6) When gallbladder stones are not combined with infection, there are usually no special signs or only mild pressure pain in the right upper abdomen. However, when the infection is acute, pressure pain and muscle tension in the middle and upper right abdomen may appear, and sometimes an enlarged gallbladder with obvious pressure pain may be found. 2. Bile duct stones. (1) When the stones are secondary to cholangitis, abdominal pain, chills and high fever and jaundice will occur. Abdominal pain mostly occurs in the subxiphoid or right upper abdomen and is mostly colicky and can radiate to the shoulder or back. The presence of jaundice is accompanied by yellow staining of the skin and sclera, darkening of the urine and lightening of the stool color. (2) Repeated cholangitis can lead to liver abscess.