Fuzzy macular structure without obvious changes is usually the conclusion given by the doctor during fundus examination or optical coherence tomography (OCT) examination. It usually indicates that the patient has refractive interstitial clouding, so only the structure of the macular area of the fundus can be seen vaguely, while the structure of the macular area without obvious changes usually suggests that there is no obvious pathology present in the macular area, but it is not absolutely certain. There are requirements for refractive interstitial transparency, both when examining with fundoscopy and when doing OCT. If the patient’s refractive interstitium is opaque, such as in the presence of cataracts, vitreous clouding and other pathologies, this can lead to an inability to visualize the fundus structures during funduscopy. The macula is the most important part of the eye for the formation of vision. If there is a change in the structure of the macula, the patient usually has significant visual impairment, and it is currently the better case that there is no significant change in the structure of the macula. It is recommended that patients presenting with macular degeneration seek prompt medical attention to evaluate their condition and follow the doctor’s instructions for treatment.