The number of patients with chronic soft tissue pain is increasing, some cases are tricky to diagnose and treat, and treatment deficits and over-treatment are common. It is like a mystery that gives doctors a headache and patients a lot of anguish. What are the other secrets of the study? 1. The lesion is deeply hidden, and the pressure and pain point cannot be found. If the lesion is in the intervertebral disc, in the intervertebral foramen, in the micro-movement joint, in the small joint, in front of the transverse process of the spine, in front of the side of the spine, etc., these hidden lesions cause neck, back, lumbar and leg pain with obvious symptoms but no pressure pain. 2. Nociceptive hypersensitivity is present. A complex change between stimulation and sensation occurs in patients with chronic pain. (1) Primary nociceptive hypersensitivity: refers to the sensitization of injurious receptors. The nociceptive impulse signal triggered by the injurious stimulus is transmitted to the center, while it is transmitted to another peripheral nerve endings at the nerve fiber bifurcation, releasing neuromediators such as substance p and calcitonin gene-related peptide in the reverse direction, stimulating platelets to release more pain-causing substances, which are regulated by the center, and eventually the stimulus is stopped but still persistently painful. The injury receptors are in a sensitized excitatory state, i.e., sensitization of the receptors occurs. The amount of protein of capsaicin receptors present in the dorsal root ganglion and the dorsal horn of the spinal cord is downregulated, and their pain threshold decreases, so that even general activity can induce nociception. (2) Secondary nociceptive sensitization, also called “touch-induced pain”, is an anatomical and chemical alteration of Aβ neurons, which originally do not transmit injurious information and do not contain substance P. The axons of Aβ neurons that do not transmit injurious information and do not contain substance P are transformed into synthetic substance P in response to inflammatory stimulation, and their axons sprout to spinal cord neurons, forming new synapses with dorsal horn pain-sensitive neurons, and non-injurious afferents can touch and enhance the activity of pain-sensitive neurons, causing the response threshold to The electrical properties of Aβ neurons in the dorsal root ganglion also changed significantly, the proportion of the number of inflammatory spontaneous discharge neurons and the frequency of spontaneous discharge increased significantly, the properties of passive and active membranes changed, the threshold decreased, and the peripheral receptive field expanded significantly. 3. Foci of secondary damage appear. For example, chronic lumbar soft tissue pain causes dorsal extensor muscle tension, and its spasm or contracture can cause back, neck, shoulder and upper limb pain, and head and occipital pain; stimulation of the posterior branch of the spinal nerve can cause hip and lower limb pain. 4. Involvement pain is present. For example, soft tissue damage in the lumbar region can cause lower extremity pain and abdominal pain; damage to the infraspinatus muscle group can cause upper extremity pain and numbness in the ulnar nerve innervation area; soft tissue damage in the neck and shoulder region can cause similar angina pectoris. 5. The presence of peripheral conduction block pain. Chronic aseptic inflammation stimulates the nerve root stem, swelling and adhesion make it act as a receptor, and the conduction of coarse fibers is blocked first, while the conduction of fine fibers still plays a role, that is, the ratio of coarse to fine fiber conduction is out of balance, so that the gates of spinal cord conduction pain are open and peripheral neurogenic pain appears. 6, sympathetic nervous system involvement is predominant. For example, soft tissue damage in the neck and shoulder area, there are complex syndromes with pain as the main cause, neck and shoulder soreness and swelling, upper limb numbness as the main cause; insomnia as the main cause; vertigo, dizziness and eye symptoms as the main cause; throat symptoms as the main cause; heartburn and chest tightness as the main cause, etc. 7, chronic soft tissue pain can cause emotional and psychological changes, such as depression or irritability, paranoia, etc. 8.Inappropriate choice of treatment method. For example, (1) non-surgical treatment does not target the lesion and does not hit the vital part of the disease. (2) The surgical treatment is not operated, and the emphasis is on conservative treatment. (3) The program of surgery is not comprehensive, such as incomplete soft tissue release; disc damage and severe lumbar instability, only the protruding disc is removed without considering the problem of stability. (4) Soft tissue damage pain combined with other pain-causing diseases, such as metabolic diseases and endocrine diseases without treatment.