Patient: Mediastinum and hilar lymph node enlargement, mediastinoscopic surgery in Sichuan West China Hospital, diagnosed as lymph node tuberculosis, now taking isoniazid (three tablets per day), rifapentine (four tablets twice a week), ethambutol (three times a day) three drugs for more than two months February 10, another CT, two months of liver function tests are normal. The result is that the lymph enlargement is not significantly smaller, but a small part of the lymph appears to be calcified. I would like to ask: 1. The doctor at Sichuan Huaxi Hospital said that if there is no problem with liver function, there is no need to take liver protection tablets, but the doctor at the local node clinic said that liver protection tablets are necessary for TB medicine. I haven’t taken any liver protection tablets so far. What should I do, doctor? Should I take liver protection tablets? 2. Is it true that TB medicine can cause damage to liver function? Is it possible to recover? Cui Yanfei, Department of Tuberculosis (Infectious Diseases), Hangzhou Red Cross Hospital: The incidence of liver damage caused by anti-tuberculosis drugs is really high, about 10%, and in a few cases, serious liver necrosis can occur, which is life-threatening. Generally, you need to take liver protection drugs at the same time, clinically there are Chinese and Western medicines, all have a certain preventive effect, you can choose according to your economic strength. The liver damage caused by anti-tuberculosis drugs will generally recover gradually after stopping the drugs.