Urticaria itches at night, mainly due to the excitation of the vagus nerve at night, and the clinical treatment can be chosen according to the manifestations of the rash. If the rash is more densely distributed, with a large area of fusion accompanied by intense itching, along with the occurrence of restricted breathing, abdominal pain, dizziness, headache, etc., then intramuscular injection of dexamethasone sodium phosphate injection and chlorpheniramine maleate injection, oral administration of olopatadine hydrochloride tablets, and topical application of furnace glycolic lotion are required. If the rash is only scattered and the itching is mild, you can apply menthol lotion and take oral fexofenadine hydrochloride tablets and avastin capsules for treatment.