For anal itching, a multi-pronged approach to medication is needed. Internal medication, external perianal application, sitz baths, and intra-anal plugs are needed. For internal use, oral dexloratadine tablets and epinastine tablets are usually recommended, one dexloratadine tablet in the morning and two epinastine tablets in the evening, which can play an anti-allergic and anti-itching role. For external application around the anus, you can use tretinoin econazole cream or hydrocortisone butyrate ointment, either one, two to three times a day. If you are looking for an anal plug, you can insert a metronidazole pessary to provide a local anti-inflammatory effect. The actual fact is that you can choose the hemorrhoid comfort lotion, if you don’t have hemorrhoid comfort lotion, you can choose the Chinese medicine such as Jieer Yin or Gynecology to clear heat, dry dampness and stop itching. If it is about ten days of medication, anal itching still does not have any improvement, it is recommended to go to the hospital, possibly due to anal pruritus caused by anal itching, at this time the medication is not able to solve the problem, the need for surgery.