The cavernous sinuses are irregular cavities located between the medial meninges and the lateral endosteal layers of the dura mater on either side of the pterygoid saddle. Cavernous sinusitis usually needs to be treated depending on the severity of the condition, usually requiring high-dose, broad-spectrum antibiotic therapy, with surgery as an option for those who develop complications. The most common pathogen causing cavernous sinusitis is Staphylococcus aureus, followed by streptococcus, gram-negative bacilli and anaerobic bacteria, and in a minority of patients by fungal infections. As a result, blood culture and drug sensitivity testing are required for treatment, and adequate and effective broad-spectrum antibiotics are given intravenously in a targeted manner. Commonly used antibiotics include nafcillin sodium, metronidazole, ceftriaxone sodium or cefotaxime. Vancomycin may be used in patients with high penicillin resistance. The course of antibiotics can be based on the patient’s clinical response and neuroimaging dynamics, usually not less than 4 weeks. Surgical drainage can be performed for the presence of primary lesions, such as sinusitis, dental infections, or concurrent intracranial abscesses and subdural pus. After the onset of the disease, you should actively seek medical treatment to improve the examination, and follow the doctor’s instructions to standardize the use of drugs and treatment.