Bone destruction at the base of the skull should be treated with general therapy, medication, physical therapy, and surgery depending on the cause. Common causes include tumor erosion, inflammatory lesions, and trauma. 1. Gradual erosion of tumor: gradual erosion of skull base tumor or brain metastasis tumor leads to bone destruction, which requires not only surgical resection of the tumor, but also surgical repair of the skull base, and even radiotherapy and chemotherapy at the later stage. 2. Inflammatory lesions: cranial osteomyelitis leads to bone necrosis, and it is necessary to remove the necrotic chronic inflammation in a timely manner, and try to remove the edge of inflammation to the normal cranial baffle area, so as to effectively control the lesion. It is also necessary to use sensitive antibiotics, standardized anti-infection treatment, such as penicillin, ampicillin. 3. Trauma: Bone destruction at the base of the skull caused by trauma requires surgical treatment, and appropriate bone repair at the base of the skull after dealing with complications (cerebral hemorrhage, etc.). There are many kinds of treatments for skull base bone destruction, which should be based on the specific cause of the disease, and early treatment under the guidance of the doctor to minimize the degree of destruction of the skull base.