Hyperlipidemia is a frequent complication of hypertension. A survey among 51 million hypertensive patients in the United States found that 40% of hypertensive patients had serum total cholesterol levels >6.2 mmol/L, and 46% of hypercholesterolemic patients with serum total cholesterol levels >6.2 mmol/L had hypertension. The higher the blood pressure, the greater the risk of coronary heart disease. Elevated serum total cholesterol levels synergistically increase the risk of coronary heart disease in hypertensive patients. In contrast, lowering blood pressure and lowering total serum cholesterol levels can reduce the risk of coronary heart disease. Hyperlipidemia is the basis of atherosclerosis, and HDL has an anti-atherogenic effect as it transports cholesterol to the liver for breakdown. Atherosclerosis tends to produce pure systolic hypertension. Conversely, hyperlipidemic patients suffering from hypertension are prone to enter the arterial intima and form atherosclerosis due to damage of the intima. Therefore, the medical community has always listed hypertension and hyperlipidemia as risk factors for atherosclerosis or coronary heart disease. Blood lipid level is influenced by many factors, including by diet structure, lifestyle and various diseases or drugs. Some antihypertensive drugs have side effects that affect lipid metabolism, so it is important to screen medications carefully for patients with high blood lipid levels. Blood lipid levels may vary from day to night due to feeding and metabolism. Generally, the value measured by taking venous blood in the morning after fasting for more than 12 hours is the standard, and it needs to be measured several times regularly to truly reflect the individual’s blood lipid level. Bile acid binding resins, niacin and its derivatives, fibrate derivatives and statin lipid-lowering drugs can be used in patients with hyperlipidemia with hypertension. However, attention should be paid to the interaction between these lipid-lowering agents and anti-hypertensive drugs. Bile acid-binding resins can reduce the absorption of thiazide diuretics and propranolol (Takayasu). Therefore, these antihypertensive drugs must be taken only 1 hour before or 4 hours after taking the bile acid binding resin. Niacin can enhance the vasodilatory effect of antihypertensive drugs and cause a drop in blood pressure, and should be noted. Fibrate derivatives may cause myopathy in some patients with renal failure; therefore, small doses of fibrate derivatives should be taken, and patients should be followed frequently. There are no specific interactions between statin lipid-lowering drugs and anti-hypertensive drugs, and they can be used in the treatment of patients with hyperlipidemia with hypertension. In addition, there are no special interactions between lipid-lowering drugs such as polyenecon and fish oil lipid-lowering pills and anti-hypertensive drugs, and they can also be used for lipid-lowering treatment in patients with hyperlipidemia with hypertension.