Positive H. pylori antibodies indicate that H. pylori infection is or has been present. H. pylori usually enters the stomach through the mouth, and most of them can be killed by gastric acid, while some of them can be attached to the mucous layer of the gastric sinus, penetrate the mucous layer through the flagellum, and colonize the mucous layer and the epithelial surface of the mucous membrane of the gastric sinus, and H. pylori infection can lead to many kinds of pathologies such as gastritis, gastric ulceration, and gastric cancer, and therefore requires timely treatment. Positive H. pylori antibodies do not completely determine the presence of existing H. pylori infection, because some patients who were once infected with H. pylori but have now been cured are also positive for H. pylori antibodies. H. pylori can be treated bactericidally with a quadruple combination of drugs, which can be co-treated with acid-suppressing drugs such as omeprazole, antibiotics such as amoxicillin and metronidazole, as well as gastric mucosal protectors such as bismuth potassium citrate. Drugs need to be applied under the advice of a doctor, and timely consultation is recommended.