Rheumatoid factor 22IU/mL is abnormal, this value is higher than the upper limit of the normal reference value, if the result is still high after retesting and combined with the patient’s related symptoms, it may suggest that the patient has rheumatoid arthritis, systemic lupus erythematosus and other diseases. Rheumatoid factor is an autoantibody closely related to autoimmune diseases, mainly IgM autoantibodies, the antibody qualitative or quantitative detection of clinical value, the normal reference range of rheumatoid factor is 0-20IU/mL, so the test result of 22IU/mL is higher than the upper limit of the normal reference range, and need to be re-tested with the specific conditions of the patient. If the result is still high after re-testing to exclude laboratory errors and other factors, it is mainly suggestive of autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, dry syndrome, scleroderma, etc. In addition, high rheumatoid factor can also be seen in the elderly, or acute and chronic hepatitis, etc. The results should be reviewed by a medical professional. Laboratory test results should be interpreted by a professional doctor, it is recommended that patients with a rheumatoid factor of 22IU/mL go to the rheumatology and immunology department of a regular hospital in a timely manner, and under the guidance of the doctor for treatment.