The most common cause of low unsaturated iron binding is high iron concentration in the body. One of the most common diseases is hemochromatosis or commonly seen in patients with iron overload due to frequent blood transfusions. Transferrin is required for the transport of iron in normal people, but only 1/3 of transferrin is able to bind to ferric ions, that is, about 2/3 of transferrin is not bound to ferric ions, and this concentration of transferrin that is not bound to ferric ions is called unsaturated iron binding capacity. A low unsaturated iron binding capacity indicates a decrease in the concentration of transferrin that is not bound to ferric ions, and a high concentration of iron in the blood, most commonly in hemochromatosis, a genetic disorder in which the concentration of iron in the blood increases due to a disorder of iron metabolism, causing liver damage, heart damage, skin lesions, and a host of other symptoms in the patient. For this disease some need regular bloodletting treatment, and some need to apply iron removal treatment with drugs such as desferrioxamine.