The most characteristic manifestation of hypoadrenocorticism is the deepening of skin pigmentation all over the body, in addition, there are also symptoms of the nervous and mental system, gastrointestinal symptoms, cardiovascular system symptoms and so on. 1. Deepening of skin pigmentation of the whole body: due to the increased secretion of pituitary ACTH and melanocyte stimulating hormone, the skin color deepens, especially in the exposed places, friction places, areola and so on, and the pigmentation of mucous membranes is mostly seen in the gums, tongue and buccal mucous membranes, and so on. 2. Nervous and mental system: often manifested as weakness, indifference, fatigue, fuzzy consciousness, etc., and even mental disorders. 3. Gastrointestinal tract: mainly manifested as loss of appetite, reduction of gastric acid, dyspepsia and so on. 4. Cardiovascular system: decreased blood pressure, dizziness, blurred vision, etc. It is recommended that patients with hypoadrenocorticism should consult a doctor in time, and after a clear diagnosis, treatment should be carried out under the guidance of the doctor.