HPV refers to human papillomavirus, and mycosis fungoides is the old name for vulvovaginal pseudomycosis. HPV 58 high-risk with vulvovaginal pseudomycosis can be treated with topical medications, systemic medications, or surgery. 1. Topical medication: HPV 58 high-risk with vulvovaginal pseudomycosis can be treated with topical interferon and clotrimazole suppositories or miconazole nitrate suppositories alternating with interferon in the vagina. 2. Systemic medication: patients can also take oral fluconazole and other antibacterial drugs to eliminate Pseudomonal yeast infection; for HPV 58 high-risk type, patients can follow the doctor’s instructions to take oral thymopeptide enteric-coated capsule, transfer factor and other drugs to improve immunity, to assist in the treatment of the disease. 3. Surgery: For patients who have not been infected with HPV 58 for a long time and have cancerous lesions, it is necessary to treat the disease by surgically removing the local lesions. Patients with HPV 58 high-risk type accompanied by mycosis vaginalis need to follow the doctor’s instructions when using medication to treat the disease; if discomfort occurs after using medication, it is recommended to consult a doctor in time.