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In biochemistry, adenosine triphosphate (ATP) is a nucleotide that serves as a “molecular currency” for intracellular energy transfer, storing and transmitting chemical energy,
ATP is an abbreviation for adenosine triphosphate, a nucleotide that acts as a “molecular currency” for intracellular energy transfer, storing and transmitting chemical energy.
The structure of the ATP molecule can be abbreviated as A-P~P~P, where A represents adenosine, P represents phosphate group, ~ represents a special chemical bond called high-energy phosphate bond, when the high-energy phosphate bond is broken, a large amount of energy will be released.
ATP can be hydrolyzed, which actually refers to the hydrolysis of the high-energy phosphate bond in the ATP molecule. The energy released during the hydrolysis of high-energy phosphate bonds is as much as 30.54 kJ/mol, so ATP is an intracellular
ATP is a high-energy phosphate compound. Huang Shen, Arrhythmia Treatment Center, Guangdong Provincial Hospital of Traditional Chinese Medicine Indication: Supraventricular tachycardia. Adenosine triphosphate is currently considered safe and effective in the treatment of pediatric supraventricular tachycardia, and has become the first-line drug to terminate episodes of supraventricular tachycardia. However, it is not effective for the treatment of intra-atrial folding tachycardia autonomous atrial tachycardia, and it cannot be applied to the retrograde type of atrioventricular folding tachycardia, otherwise it tends to accelerate the ventricular rate and even the occurrence of ventricular fibrillation. Dosage
Dose: The first dose of 0.1mg/kg should be injected intravenously within 3-5s, if it is ineffective, the second dose can be injected after 3 minutes of ineffectiveness, and each time increase according to 0.05-01mg/kg until the maximum amount
0.25-0.3mg/kg or termination of tachycardia. The injection site should be in the upper extremity or in the blood vessels close to the heart, otherwise it is easy to fail or requires a large dose, and the side effects increase with increasing dose. If the injection is followed by
If severe bradycardia occurs after injection, aminophylline can be used to relieve it at a dose of 5-6 mg/kg for more than 5 minutes; atropine is prohibited. Side effects and precautions: facial flushing, excitation of asthma, sinus arrest, atrioventricular block, respiratory and cardiac arrest, and decrease in blood pressure. Efficacy depends not only on the dose and rate of administration of adenosine triphosphate, but also on the heart spacing, vagal and adrenergic tone at which the needle is administered. Contraindications: Contraindicated in children with asthma and in those with hypersensitivity to adenosine triphosphate.