Minimally invasive interventional therapy is a new mode of tumor treatment, integrating medical imaging technology, drug therapy, biological, genetic technology and high-tech medical technology (such as radiofrequency, microwave or cryoablation, particle implantation, laser, ultrasound focusing, endoscopy, lumpectomy, photodynamic therapy, etc.) into one, using physical, chemical or biological methods to directly kill solid tumors in situ. Minimally invasive treatment has developed from local injection of anhydrous ethanol (chemical ablation) to modern radiofrequency ablation, microwave ablation, cryoablation, radioactive particle implantation and many other new technologies, and is progressing rapidly. Radiofrequency ablation is one of the more mature and minimally invasive treatment methods. Radiofrequency ablation ( radiofrequency ablation, RFA ): Radiofrequency ablation is to send out high frequency radiofrequency current (frequency reaches 150,000 times per second) through radiofrequency electrode, under the high frequency oscillation, the ions in tumor tissues and cells vibrate at high speed and generate heat by mutual impact (the ablation electrode itself does not generate heat). The temperature of the ablation zone reaches above 90℃, thus causing tissue dehydration, protein denaturation, cell membrane disintegration, thermal coagulation necrosis and denaturation of tissue cells to achieve ablation. Indications: Patients who are not suitable for surgery, radiotherapy and chemotherapy, patients with recurrence or residual after surgery, or patients with recurrence or insensitive solid tumors after radiotherapy or chemotherapy. It is especially useful for elderly tumor patients who cannot or do not want to undergo surgery and cannot receive radiotherapy or chemotherapy, or patients with other serious underlying diseases. Small lesions can achieve the same effect as surgical treatment. Features: no surgery, minimal trauma, few complications, precise localization, safe treatment, and short hospital stay. CT scan determines the location of the lesion, selects the puncture point and direction, punctures the tumor tissue with CT-guided ablation electrode, and opens the electrode to the appropriate diameter for ablation according to the size of the lesion, and electrocoagulates the needle tract after treatment to avoid bleeding and metastasis. After treatment, regular follow-up examinations should be performed to detect possible local recurrent lesions and new intrahepatic lesions in a timely manner, so as to effectively control tumor progression by utilizing the advantages of minimally invasive and simple percutaneous ablation that can be performed repeatedly. Male, 78 years old, primary hepatocellular carcinoma. He underwent radical radiofrequency ablation for hepatocellular carcinoma due to severe COPD, which could not tolerate surgical treatment.