Sartans and diphenhydramines can be taken together, diphenhydramines and prilosec can be taken together, and sartans and prilosec cannot be taken together. Sartans (ARB class) are angiotensin receptor antagonists, such as irbesartan tablets, diphenhydramine (CCB class) are calcium channel blockers, such as nifedipine tablets, and puri drugs (ACEI class) are angiotensin converting enzyme inhibitors, such as captopril tablets. All three are commonly used drugs in cardiovascular medicine, mainly used in the treatment of hypertension, coronary artery coronary atherosclerotic heart disease (coronary heart disease) and so on. Sartans and Prilosec are in the same class of drugs, generally not recommended for joint use, when the use of Prilosec appears cough, edema and other adverse reactions or the existence of contraindications to the use of Prilosec can be replaced with Sartans. And diphenhydramine class drugs and the above two different mechanisms of action, can be used jointly. The specific use of drugs and drug change should be carried out under the guidance of clinicians.